Mieke De Groote graduated from the Studio Herman Teirlinck drama school in 1981.
She has collaborated with several major Belgian and Dutch theater companies over the decades, including Het Toneelhuis, KVS, NTGent, De Nwe Tijd, Theâtre National, Les Ballets C de la B, The Royal Opera House, De Tijd, Orkater, Theater Rotterdam, Hollandia a.o.
On television, she has appeared in productions such as Het eiland, Van Vlees en Bloed, Cordon, Beau Séjour, Amateurs, De Twaalf, Tytgat chocolat, Patrouille Linkeroever, Zie mij graag, Billie vs Benjamin, and films such as The Vanishing, Rosie, De Hel van Tanger, Hellhole, Holy Rosita, a.o.
In 2025, she won the Ensor Award for Best Supporting Role in Holy Rosita by Wannes Destoop.
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